36 



THE ROYAL SOCIETY OF CANADA 



misleading since a more marked wastage of certain tissues would 

 lead to apparent increases in others. The deficient diet appears to 

 produce an increase in liver, heart, and kidneys (the percentage 

 figures are higher than the controls, even when calculated on the 

 basis of body-weight prior to treatment), but it is doubtful if these 

 are more than the relative increases produced in starvation. The 

 adrenals show no actual enlargement on deficient diet only, though 

 the percentage figures are distinctly higher. No marked differences 

 are seen in the thyroid figures, and it was noted that on the deficient 

 diet the thyroid does not enter into the resting condition (as under 

 thyroid treatment, when the gland is noticeably pale at autopsy) 

 but is bright red in colour and apparently functioning actively. 

 This holds true also in the combined treatment. Both thyroid 

 treatment and diet deficiency produce marked loss of body-fat. 



A much larger number of experiments are evidently necessary for 

 definite conclusions. Unfortunately the combined effects of the 

 thyroid and vitamin deficiency usually give such an early fatal result 

 that the changes in body organs cannot become very marked. 



We wish to acknowledge the assistance of Mr. J. Carmichael in 

 carrying out some of the experiments. 



TABLE VI 



Expt. 



Percentage Gain or Loss in 



Weight 



Percentage Gain or 

 Loss in Weight com- 

 pared with control as 

 Standard 



Sum of 



C-t-T) and 



(-V) 



2 

 3 



4(F) 

 4 (M) 



-78 

 -66 

 -63 

 -84 



REFERENCES 



Cameron, A. T., and Carmichael, J., J. Biol. Chem., 1920, xlv, 69; 



1921, xlvi, 35. 

 Herring, P. T., Quart. J. Exp. Physiol., 1917, xi, 231. 

 Hoskins, E. R., J. Exp. Zool., 1916, xxi, 295. 

 Kellaway, C. H., Proc. Roy. Soc, (B), 1921, xcii, 6. 

 McCarrison, R., Proc. Roy. Soc, (B), 1920, xci, 103. 

 Vincent, Swale and Hollenberg, M. S., Endocrinology, 1920, iv, 408; 



Proc. Physiol. Soc, Ixix, J. Physiol. 1921, liv. 



