[banting, etc.] effect OF INSULIN ON R.Q. OF DOGS 37 



Dog IV.— R.Q. 0.63 (48 hrs. after pancreatectomy); after 25 

 gms. sucrose it rose to 0.70 (in 52 min.) returning to 0.65 in 1 hr. 

 35 minutes. Two days later 5 c.c. insulin followed in 1^ hours by 

 30 gms. sucrose caused the quotient to rise to 0.83 in about 1 hour 

 after the sucrose. On Feb. 20th, six days after pancreatectomy, this 

 animal was fed sugar ad lib. 10 c.c. of insulin then caused R.Q. to rise 

 from 0.76 (on the previous day) to 0.95. 



Dog V. — Sucrose caused a decided rise in R.Q., from 0.67 to 0.81, 

 in 51 hours and a smaller rise (from 0.69 to 0.73) in 107 hours. On 

 the sixth day 8 gms. dextrose was injected subcutaneously along with 

 10 c.c. insulin only raised R.Q. from 0.73 to 0.80. 



Dog VI. — This animal was not depancreated but was starved 

 for three days. It was given 4 c.c. insulin subcutaneously with the 

 result that R.Q. rose from 0.77 and 0.75 to 0.90 (in 42 minutes after 

 injection) and then fell to 0.85 (in 1 hour 6 minutes) and 0.78 (in 1 

 hour 36 minutes). 



Although the above observations were not as adequately con- 

 trolled as we should have desired, they show conclusively that insulin 

 given along with sugar to depancreated dogs raises the Respiratory 

 Quotient to a much higher level than occurs with sugar alone. 



