(banting, etc.] effect OF INSULIN ON FAT AND GLYCOGEN 41 



The results so far obtained on the fat of blood show insulin to 

 have a decided reducing effect. 



The observations taken as a whole show that insulin given to sugar- 

 fed diabetic animals causes the fat to become reduced in the liver at 

 the same time as glycogen accumulates. Whether glycogen would 

 also accumulate in this organ without ingestion of sugar, we cannot 

 at present say. It is clear that there must be a stage following the 

 administration of insulin when glycogen and fat both are present 

 in considerable percentage in the liver. This is shown in experiment 

 56. The protocolls of these experiments are given in abbreviated 

 form in Table I. 



References 

 Cruickshank, E. W. H. Jour. Physiol. 1913, xlvii, p. 1. 

 MACLEOD, J. J. R. and Prendergast, D. Trans. Roy. Soc. Can., 

 1921, Sec. V, p. 37. 



