ADSORPTION BY SUSPENSIONS OF VARIOUS SUBSTANCES. 219 



witli a volume corresponding to one lethal dose, and two injected with volumes 

 corresponding to two lethal doses lived a little longer than their controls; 

 none, however, survived. Two of eight animals injected with supernatant 

 fluid from the heloderma Ijrain and dry venom mixture lived longer than their 

 controls, but here also no animals survived. As might be expected from these 

 results, the two mice injected with the heloderma brain-venom residue sur- 

 vived. The larger particles, which constitute the mass of the heloderma 

 brain suspension, adsorb, therefore, very little venom, while to judge from the 

 experiments with dog brain, to be reported later, a considerable part of the 

 venom has been adsorbed by the small particles of brain contained in the 

 supernatant fluid. 



Heloderma liver adsorbed a small quantity of fresh venom; all five mice 

 injected with the supernatant fluid from this mixture lived longer than their 

 controls, and all but one lived 24 hours after the injection. AVith the dis- 

 solved dry venom solution the heloderma liver adsorbed as much as 85 per 

 cent of the venom, but frequently less than 70 per cent. In some experiments 

 mice injected with the smaller dose died, while in other experiments animals 

 injected with a quantity equivalent to 6f lethal doses survived. 



Two animals injected with the residue from the heloderma-liver venom 

 mixture died, and two animals survived. On the whole, therefore, the liver 

 of heloderma adsorbs a considerable part of the venom. 



The adsorptive power of heloderma kidney, when mixed with fresh 

 venom, was tested in only two animals, both of which died. They both, how- 

 ever, survived their controls for a considerable time; one had received a 

 quantity of supernatant fluid corresponding to one lethal dose, the other a 

 quantity corresponding to two lethal doses. 



When heloderma kidney was mixed with a solution of dry venom, as 

 much as 85 per cent of the venom was adsorbed in some cases, while in others 

 less than 70 per cent. Four mice were injected with residue from the helo- 

 derma-kidney venom mixture; one of these died and three survived. In the 

 cases when the residue was not toxic, the venom had possibly been held more 

 firmly by the pulp, or it had been washed out with the salt solution used to 

 wash the residue. The latter interpretation is, however, less probable. From 

 all these experiments we may conclude that heloderma liver and kidney adsorb 

 a considerable amount of venom. 



One mouse injected with a mixture of venom solution and heloderma 

 serum died approximately at the same time as its control. 



Turtle brain, like heloderma brain, adsorbed apparently very little 

 venom. Two mice injected, respectively, with one and two lethal doses of the 

 supernatant fluid from the turtle-brain and venom mixture, lived only a 

 little longer than their controls. The majority of the mice injected with the 

 supernatant fluid from the mixture of turtle brain and dissolved dry venom 

 died as soon as their controls. Two mice out of nine, however, survived the 

 injection; one of these had been injected with a quantity of fluid correspond- 

 ing to 6f lethal doses; but as in this experiment the mouse injected with SJ 



