ADSORPTION BY SUSPENSIONS OF VARIOUS SUBSTANCES. 221 



The action of frog kidney was tested on 9 mice, only 1 of which (an animal 

 injected with a large quantity of the supernatant fluid), died in as short a time 

 as the control; 1 which had received a quantity corresponding to only 85 

 lethal doses of venom, survived, while 7 lived longer than their controls. Frog 

 kidney adsorbs, therefore, a small quantity of venom, but less than heloderma 

 or turtle kidnej'. 



Frog-kidney venom residue was injected into 3 mice, none of which died. 

 Since frog kidney adsorbs a small quantity of venom, frog kidney, like turtle 

 liver and kidney and heloderma kidney, either holds the adsorbed venom suffi- 

 cientlj' firmly to prevent the venom from being adsorbed very rapidly by the 

 injected mouse or it destroys the adsorbed venom. 



Three animals injected with the supernatant fluid from pigeon-brain 

 venom mixture died as soon as their respective controls; one injected with the 

 residue from the pigeon-brain venom mixture survived. Since the supernatant 

 fluid from this mixture contained fine particles of brain matter, we can not 

 exclude the possibility that pigeon brain adsorbs a certain amount of venom; 

 it seems, however, that the quantity of venom adsorbed is small. 



Of 9 mice injected with the supernatant fluid from pigeon-liver venom 

 mixture, 2 injected with large quantities died as soon as their controls; 3 lived 

 longer, while 4 survived the injection. Of the 4 surviving animals, 2 had been 

 injected with quantities of venom corresponding to 83 lethal doses, 1 with a 

 quantity corresponding to 6f lethal doses, and 1 with a quantity corresponding 

 to ISf lethal doses. We may therefore conclude that pigeon liver adsorbs a 

 certain amount, approximately from 70 per cent to 80 per cent of the venom. 

 This conclusion is confirmed by an experiment in which 3 mice were injected 

 with the residue from the pigeon-liver venom mixture; 2 of these died and 1 

 survived. 



The supernatant fluid from a pigeon-kidney venom mixture was injected 

 into 6 mice; 4 died as soon as the controls; 1, which had been injected with a 

 quantity corresponding to 6f lethal doses, survived the injection. Pigeon kid- 

 ney, therefore, seems to adsorb somewhat less venom than pigeon liver. Of 

 the two animals injected with pigeon-kidney venom residue, one survived the 

 injection. 



Of 5 mice injected with the supernatant fluid from the mixture of fresh 

 venom with the pulp of the whole brain of rabbits, 4 died as soon as the controls ; 

 the fifth lived a little longer than the control. Of 4 injected with the super- 

 natant fluid from a mixture of venom with the gray matter of rabbit brain only, 

 2 lived longer than the controls, while the others died as soon as the controls. 



In an experiment in which the white matter of rabbit's brain was used in 

 place of the gray matter, 3 animals out of four lived longer than the controls. 

 Here again a certain amount of venom had probably been adsorbed by the very 

 small particles of the brain emulsion. 



In 2 cases in which supernatant fluid from a fresh-venom rabbit-liver mix- 

 ture was injected into mice, the animals died as soon as the controls. Of 3 

 mice injected, 2 with 13J lethal doses, and 1 with 6| lethal doses, respectively, 

 from this rabbit-liver dry-venom mixture, died as soon as their controls, whereas 



