270 Report S.A.A. Advancement of Science. 



TRANSMISSION OF HEART-WATER FROM GOATS TO 



CATTLE. 



A clean ox from a sweet veld area was inoculated by the in- 

 jection of 5 c.c. subcutaneously and 5 c.c. intravenously of blood 

 from a goat which was dying of Heart-water. 



On the i5tn day after inoculation the temperature began to rise, 

 reaching during the evening to io6"4. During the five days sub- 

 sequent it was maintained about 105F. without remission, but the 

 following morning it fell to loi'S, and on the same evening ascended 

 to 1 07 "2. It died two days later. 



On making a post-mortem examination, I found the pericardium 

 filled with fluid. There was some interlobular pulmonary infiltra- 

 tion, and indeed there were produced conditions similar to those we 

 are accustomed to find in goats dying of Heart-water. 



On the 1 6th day of the disease it was bled, and after defibrina- 

 tion of the blood a goat was inoculated by the injection of 10 c.c. 

 subcutaneously and 10 c.c. intravenously. 



This goat died seventeen days later of typical Heart-water. 



The type of fever induced in cattle by the inoculation of Horse- 

 sickness blood is practically the same as that obtained by the inocu- 

 lation of the same species of animal with Heart-water blood. 



The post-mortem conditions are likewise identical, and agree in 

 all particulars with those found in the endemic disease occurring 

 in cattle, and known to the Kafirs as Impunga, while having shown 

 typical cases to experienced transport riders they have assured me 

 that it is known to them as Veld-sickness. 



As I have already said, Karoo cattle coming to the coast areas 

 are liable to become attacked, the coast cattle remaining in perfect 

 health. 



Transport riders assure me that cattle from these coast areas can 

 ^avel throughout the whole of South Africa, except in the Tsetse 

 Fly belts. 



I have ascertained that this disease occurs on the velds on which 

 Heart-water is known to exist. 



THE CO-RELATION OF VELD-SICKNESS AND HEART- 

 WATER. 



Experiment 5. — To determine the relation of Impunga or Veld- 

 sickness in cattle to Heart-water in goats. 



With blood taken from a Graafif-Reinet calf dying of Veld- 

 sickness I inoculated Goat No. 312 on December i6th by the intra- 

 venous injection of 30 c.c. of the blood. 



The temperature began to rise on the 5th day, and the animal 

 died on the 15th day of Heart-water. 



The post-mortem conditions were absolutely typical of Heart- 

 water occurring spontaneously among goats. 



