274 Report S.A.A. Advancement of Science. 



Two days later, Mr. Dalton proceeded to another camp, and, 

 having shot a horse there, brought to me the heart and lungs " en 

 masse." 



The conditions found here were identical with the foregoing 

 case, but rather more aggravated in type. . 



I cannot regard these and similar observations which I have 

 made otherwise than as indicating that the condition which I pro- 

 duced in clean horses by Heart-water blood inoculation and also by 

 the injection of the blood of Horse-sickness inoculated donkeys is of 

 the same nature as that which existed among the horses of the protec- 

 tion camps. 



In cases where I carried my experimental inoculations so far as 

 to produce perfect protection against Horse-sickness, the animals 

 immediately thereafter began to put on flesh. 



TRANSMISSION OF HORSE-SICKNESS FROM HORSES 10 



GOATS. 



As I have already said, the inoculation of even a large dose of 

 Hc^rt water blood into a horse may fail to be attended with any 

 very definite result. 



Conversely, the inoculation of Horse-sickness blood into goats 

 was attended with uncertain results. In my first experiments, out 

 of seventeen inoculated at different times, a febrile reaction occurred 

 in only ten, and none died. These goats, however, were obtained 

 from Mr. Palmer's farm. 



Since then I have used absolutely clean goats, and have had 

 further success. 



On the yth March, 1893, I inoculated goat No. 381 with 20 c.c. 

 of fresh Horse-sickness blood by intravenous injection. It died three 

 days later. 



On post-mortem examination I found an enormous interlobular 

 exudation into the lungs and pericardium. In the latter the whole 

 exudation was absolutely solid. 



This remarkable result is somewhat to be compared with experi- 

 ments which I made a few years ago in inoculating a goat and a 

 sheep with the serum of a " salted " goat which had been re-infected 

 by inoculation a week previously. 



The sheep and goat were inoculated in the forenoon, and were 

 found dead the next morning with .symptoms very similar to those 

 just recorded. 



With the blood of Goat No. 381 I now inoculated No. 383 by 

 intravenous injection of 5 c.c. of defibrinated blood on the 9th 

 March. 



Some fever followed, and on the loth day it had a temperature 

 of 106, making, however, a good recovery. 



On the 20th March I bled this goat, and inoculated No. 393 

 with 5 c.c. by intravenous injection. 



