' NAT. ORDER. — CINCHONACE.E. 33 



Dr. James Osgood, of Boston, Mass , informed me that while he 

 was engaged in the practice of medicine in some of our Western 

 States, in the years 184C and 1847, he made extensive use of the 

 Cinchona, in the treatment of fevers so prevalent in that portion of 

 the country- ; and in all cases where the directions had been faith- 

 full\- attended to, the chills and fever were invariably broken up, 

 either on the second or third day. He advises its use in connection 

 with other articles, and compounded after the following manner, 

 viz. : Take equal parts of cinchona ruba peruvian bark, diospyros 

 virginiana persimmon bark, (of the root.) and corallorhiza odontor- 

 hiza crawley root. Let them all be finely pulverised and well mix- 

 ed together, and exhibit half an even tea-spoon full in a gill of cold 

 water, once an hour, for six hours. This treatment," says Dr. Os- 

 good, " I have usually preceded with an emetic, and have invaria- 

 bly found it efficacious in removing the febrile symptoms within the 

 time above specified. In very severe cases I have added to each 

 dose one or two grains of Quinine. This mode of treatment is ap- 

 plicable to all the fevers of the Western country, and is decidedly 

 the best that I have ever pursued. It produces speedy and profuse 

 perspiration, to which the fever shortly yields. 



How far the same treatment would be applicable to the fevers 

 of this region, I am unable to determine, having had but a single 

 opportunity to test it. That was a case of Pleurities, pleuricy, in 

 which it equalled my most sanguine expectations. It may be well 

 to remark that it would be injudicious to continue the use of the 

 medicine longer than about six hours, as the perspiration would 

 cause too much debility. In connection with the treatment it is my 

 uniform practice to keep the bowels open." 



TINCTURE OF QUININE. 



Take of siil[)hate of Quinine - - 6 grs. (gr. 4. 92 trov.) 

 Alcohol of 34" (847) - - 1 oz. (7 dr. 52. 5 gr. troy.) 

 We are told that the sul[)hate is to be preferred to the pure 

 quinine, in this case; because when the tincture is made by using 



