PERSISTENLY TESTED: 383 
symptoms of Cobra poisoning resulted, but after the develop- 
ment of symptoms of Cobra poisoning, permanganate of potash 
failed to have any effect whether injected locally, into a vein, 
or both.” 
These results were also obtained by Lacerda (Couty and 
Lacerda, Comptes Rendus, Vol. xcii., p. 465), and by Richards. 
PERSISTENTLY TESTED. 
Many experimenters at first were very discouraged and 
inclined to think permanganate of potash was of no practical 
value, for it was found that when rabbits, pigeons, and fowls 
were injected with venom and the wounds immediately scarified 
and permanganate rubbed in, the creatures in most cases died. 
It must, however, be borne in mind that these species of animals 
are extremely susceptible to the poison of snakes, and that in 
these experiments, doses of venom averaging from five to fifty 
fatal doses had been administered at one injection. Such a 
comparatively large quantity of venom being introduced caused 
enough to get into the general circulation to kill these highly- 
susceptible animals, in spite of the permanganate neutralizing 
the venom not yet absorbed from the site of the injection. It 
was noted, however, that the application of the permanganate 
delayed death in most instances. 
Much more satisfactory results were obtained with animals 
of a higher order whose bodily organizations were more akin to 
that of human beings, such, for instance, as monkeys, cats, and 
dogs. Dr. Lauder Brunton and several others found that cats 
recovered when permanganate was rubbed into the incisions 
made over the site of the injection, although ten ordinary fatal 
doses of venom had been given, or in other words enough venom 
was injected at a dose into each cat to kill ten cats, and when 
permanganate was applied the animals recovered. 
These experiments were carried out extensively, and in all 
but two or three cases the animals recovered. 
In Dr. Brunton’s experiments the venom was first injected, 
a ligature applied, the flesh over the site of the injection deeply 
scarified, and permanganate rubbed into the tissues. After five 
minutes the ligature was removed. The animals experimented 
on received an average of five to ten ordinary fatal doses at a 
single injection, yet they recovered. 
