EXPERIMENTAL METAPLASIA 



I. THE FORMATION OF COLUMNAR CILIATED EPITHELIUM 

 FROM FIBROBLASTS IN PECTEN 



G. HAROLD DREW 



Beit Memorial Research Fellow 



EIGHT FIGURES (tHREE PLATES) 



CONTENTS 



Introduction and review 349 



Description of tissues involved in the experiments 353 



Methods 356 



Results of the implantation of pieces of the mature ovary into the adductor 

 muscle, and the subsequent development of ciliated epithelium from the 



fibroblasts formed around it 359 



Experiments to determine more exactly the relation of the presence of ova- 

 rian tissue to the formation of ciliated epithelium from fibroblasts 364 



Summary of results of experimental work 369 



Discussion of results 370 



Abstract of experiments performed 373 



Literature cited 374 



INTRODUCTION AND REVIEW 



The experiments described in this paper were performed on 

 Pecten maximus and Pecten opercularis at the Plymouth Labor- 

 atory of the Marine Biological Association of the United King- 

 dom. 



In the course of some investigations as to the mode of formation 

 of new fibrous tissue in Pecten, undertaken by Mr. W. De Morgan 

 and myself (Drew and De Morgan '10) we transplanted various tis- 

 sues, such as the digestive gland, gills, gonad, etc., into the mid- 

 dle of the adductor muscle, and studied the process of fibrous 

 tissue formation around the implanted mass. We also injected 

 sterile Agar jelly made with sea water, and since then I have per- 

 formed similar experiments with sterilised cotton wool, cork, elder 



THE JOURNAL OF EXPERIMENTAL ZOOLOGY, VOL. 10, NO. 4 

 MAY, 1911 



349 



