EFFECT OF CASTRATION ON THE WHITE RAT 313 



9. Relations of sex glands to hypophysis. After removal of the 

 sex glands, it appears that when compensatory growth of the 

 hypophysis occurs, then there is no overgrowth or obesity. On 

 the other hand, both these effects follow when the enlargment 

 does not occur, as in the spayed rats. 



In the semi-spayed, neither enlargement of the hypophysis nor 

 overgrowth and obesity occur because the enlargement of the 

 remaining ovary enables it to furnish the normal amount of ova- 

 rian secretion. 



LITERATURE CITED 



Barnabo, V. 1908 Sui rapporti tra la glandola interstiziale del testicolo e le 

 glandole a secrezione interna. II Policlinico, vol. 15, pp. 134-144. 



Bond, C. J. 1906 Some points in uterine and ovarian physiology and pathology 

 in rabbits. Brit. Med. Jour., vol. 2, pp. 121-127. 



1906 The by-effects of hysterectomy and oophorectomy. Brit. Med. 

 Jour., vol. 2, pp. 733. 



Carmichael, E. S. and Marshall, F. H. ^. 1908 On the occurrence of compen- 

 satory hypertrophy in the ovary. Jour, of Physiol., vol., 36, pp.431— 434. 



Gushing, H. 1909 The hypophysis cerebri, clinical aspects of hyperpituitar- 

 ism and of hypopituitarism. Jourm. Amer. Med. Assoc, vol. 53, pp. 

 249-255. 



Donaldson, H. H. and Hatai, S. 1911 Note on the influence of castration on 

 the weight of the brain and spinal cord and on the percentage of water 

 in them. Jour. Comp. Neurol., vol. 21, pp. 155-160. 



FicHERA, G. 1905 Sur I'hypertrophie de la glande pituitare consecutive k la 

 castration. Archives Ital. de Biol., vol. 43, p. 405. 



Hatai, S. 1913 On the weights of the abdominal and thoracic viscera, the se.x 

 glands, ductless glands and the eyeballs of the albino rat (mus nor- 

 vegicus albinus) according to body weight. Amer. Jour. Anat., vol 15, 

 no. 1. 



Jackson, C. M. 1913 Post natal growth and variabilitj' of the body and of the 

 various organs in the albino rat. Amer. Jour. Anat., vol. 15, no. 1. 



Kon, J. Hypophysenstudien. 2. Uber das Verhalten der Hypophyse nach 

 Kastration. Ziegler's Beitrage zur pathologischen Anatomie und zur 

 allgemeinen Pathologie, vol. 64, p. 233. 



Lannois et Roy 1902 Des relations qui existent entre I'etat des glandes 

 genitales males et le developement du squelette. G. R. de la Soc. de 

 Biol., vol. 55. 



Marrassini, a. 1910 Sur les modifications que la castration peut determiner 

 dans les organes glandulaires de quelques animaux, et specialement 

 sur celles que Ton recontre dans I'hypophyse. Arch. Ital. de Biol., vol. 

 53, pp. 419-431. 



