Hatai, Spinal Ganglion Cells. 39 



SjovALL ('03) has pointed out these structures in the human 

 nerve cells, in a patient dying from tetanus, and gave many fig- 

 ures showing different stages of the processes of the formation 

 of the granules. Sjovall showed further an accumulation of 

 basophile granules along the nuclear membrane where the pro- 

 cesses are covered. He concluded Irom these observations that 

 "Die gesehenen Veranderungen sind als von der tetanischen 

 mptorischen Erregung verursachte, innerhalb voUig physiolog- 

 ischer Grenzen sich abspielende Aktivitatserscheinungen aufzu- 

 fassen, und nur als solche. Zu dieser Ansicht komme ich : 

 (i) Weil sie den experimentell hervorgerufenen Aktivitatsver- 

 anderungen der Nervenzellen wesentlich gleich sind. Dies be- 

 trifft ; (a) sovvohl die friiher gesehenen Veranderungen, (b) wie 

 die von mir gefundene Beziehung zwischen Kern und Proto- 

 plasma, die mit den Befunden von Holmgren identisch ist, und, 

 wie diese, sicher als einen Restitutionsvorgang des wahrend der 

 Aktivitat in anspruch genommenen Tigroids zu deuten ist." 



The writer had a chance to examine several preparations 

 of the nerve tissue of rat, cat, dog and man under pathological 

 as well as under experimental conditions and found always the 

 pseudopodia like processes at one side of the nucleus. This 

 phenomenon was more clear when the nucleus was located 

 eccentrically ; the pseudopodia being extended toward the main 

 portion of the cell body. These observations show changes 

 in the cell body and nucleus corresponding to those occurring 

 during foetal life. 



Grotvtk changes in the ?ierve cells. — As soon as the pseudo- 

 podia-like processes have disappeared marked changes take place 

 In the structure of the nucleus The most notable changes are : 

 (i) the nucleus assumes a spherical or oval shape with a smooth 

 outline ; this shape is maintained during life ; (2) the chromatic 

 granules (basophile) which existed abundantly along the nuclear 

 membrane disappear and at the same time some of the granules 

 move towards the center where they surround a cluster of the 

 acidophile granules and form a permanent nucleolus ; (3) most 

 of the basophile granules are changed into oxyphile granules 

 as is shown by the change in staining capacity, since the orig- 



