62 ANDREWS. 



tural reduction of the peripheral portion, there appears to be 

 increased irritability to stimuli of all sorts, the tactile powers of 

 the substance in the widest meaning of the term receiving 

 emphasis.^ 



[6i] The optical quality and structure of nerve lines of the con- 

 tinuous substance is extremely like that of the "granules," and 

 like "chromatin " in all its different groupings as inclusions of 

 the finer foam. The similarity of staining reactions of both 

 these structures and also of nerve tissues is another likeness 

 between them. In actual nerve lines of continuous substance 

 I have not seen granules present as such. All these structures 

 alike are more or less unstable organizations of the interalveolar 

 foam, and can by redistributions along its lines become imper- 

 ceptible as distinct areas, though they seem then to impart a 

 characteristic optical quality to the whole area in which they lie 

 hidden. 



\p2\ To all of these there must be conceded the value of sub- 

 stance organs, as well as of organs of the organism ; and the 

 full significance of protoplasmic habits of self-expression. 



As to those granules which, either in their specific form or 

 in more finely diffused states, are inseparable comrades of the 

 living substance, one is constrained to impute to them some 

 direct relation to constant and characteristic activities of the 

 substance in which they are imbedded, — that is, the continu- 

 ous substance, for of this they are at all times inclusions, and 

 at some times compound inclusions. 



I could not determine whether the peculiar optical character 

 of these inclusions were due to their included substance, or to 

 the character of the continuous substance forming their walls 

 and possibly a reticulum. I am inclined to think, however, 

 that their refractive quality pertains to their form, and their 

 marked tingibility pertains to the nature of their included sub- 

 stance. Later, when the facts have been given in relation to 

 strial modifications of the continuous substance, this will be 

 understood as not a mere guess, but as legitimate inference. 



[63] Protoplasmic differentiations may be summed up as of 



^ This will be more fully discussed in a paper now in preparation for the press, 

 dealing with end-organs, consciousness, etc. 



