Emigration in Passive HypercBmia. 39 



bers, the shortest time of exit observed being twenty minutes 

 — the average one to two hours. The method of locomotion 

 did not, of course, differ from that exhibited in inflammation, 

 though at no time did I observe the excessive change of form 

 and protrusion of long processes figured in the books. There 

 was frequently a flattening of the leucocyte against the wall; 

 then the appearance of a bud external to the wall; then the 

 gradual enlargement of this bud and shrinkage of the intra- 

 vascular portion, the part piercing the wall being apparently a 

 tunnel through which the rest of its body passed. Often the 

 locomotion was continued after the leucocyte had become 

 wholly extra-vascular, so that it traveled several times its own 

 diameter from the place of exit. It was noticed, too, that 

 other corpuscles were prone to pass out at the particular point 

 of previous migration, so that sometimes several would be 

 crowded together along the vascular wall, and an hour later 

 would be in close proximity, external to the vessel opposite the 

 same point. 



This phenomenon occurred usually not in the minutest capil- 

 laries but rather in the large capillaries and small veins, rang- 

 ing from 1-5V0 to -g-^ inch in diameter. Nor were the passages 

 always made where the current was slowest, nor where the 

 vessel gave evidence of greatest engorgement — by the crowd- 

 ing of the corpuscles — as emigration from a rapid current but 

 sparsely supplied with corpuscles was not infrequent. 



Before I had watched the process a great while I became 

 aware that the colorless corpuscles were not the only bodies ex- 

 hibiting amoeboid movements. I observed that certain red 

 ones without nuclei, of circular shape and small size {^-^^ inch 

 in diameter), performed the same movements with as great 

 celerity as did the white. (The listener is reminded that in the 

 frog the perfect red corpuscle is of elliptical shape, is -^4-^^ inch 

 in its longer diameter, and has a distinct nucleus; while the 

 white globule is, when at rest, of circular shape, its diameter 

 only about ^-^-^ inch.) There could be no possibility of con- 

 founding these small red ones with the white, for although in 

 size, shape, and movements, they were identical, the red color 

 of some was unmistakable. So extensive was the locomotion 

 of the red ones that at the 36th hour of the experiment there 

 were numerous red patches in the field, which looked almost 

 like hemorrhages. That they were not hemorrhages I knew, 



