THE HYPOPHYSIS IN REPTILES 263 



views and believed the cells to be in different functional stages, 

 of which the granular acidophilic cells represent the completed 

 stage of secretory elaboration. Apparently Cushing ('12) is 

 inclined toward the former view and Herring ('08 and '13) 

 toward the latter. In the turtle and alligator material which I 

 have studied, deeply basic-staining, granular cells, acidophilic 

 granular cells and large clear cells are found. In the latter 

 the nuclei are central in position. In snakes and lizards, cells 

 taking varying amounts of eosin and others quite clear, are 

 present. Unlike Herring's results, tubules containing colloid sur- 

 rounded by clear cells were not found in turtles. Both granular 

 and clear cells are always present. In alligators and turtles 

 there are many of the deeply-staining cells, both acid and basic, 

 in the center of the anterior lobe, while Tilney found the basic 

 cells usually at the periphery. Although Haller ('96) described 

 and figured a granulation toward the lumen or center of the 

 cord, my material shows both proximal and distal granules, 

 with possibly more at the basal end. 



The author realizes with Herring ('08) that "It is extremely 

 difficult to decide whether these appearances indicate distinct 

 forms of cells or whether they are merely expressions of different 

 functional stages of one and the same kind of cell." Since, in 

 reptiles, some of the cells are densely-staining (acid or basic), 

 often with basal nuclei, and others scarcely stainable, with cen- 

 tral nuclei, it would seem that the latter may be cells which at 

 the time contain no secretory granules. That the presence of 

 two distinct kinds of cells in the anterior lobe can be explained 

 by an ectodermal and an entodermal origin (Miller '16) seems 

 doubtful. In the pars tuberalis and the part surrounding the 

 anterior lobe, large clear polyhedral cells are present, and, in the 

 latter part, occasional tubules lined by low, columnar, dense- 

 staining cells occur. Staderini ('05) stated that the isolated 

 masses derived from the lateral lobes in Gongylus are histologi- 

 cally like the remainder of the hypophysis, while Sterzi ('04) 

 and Tilney ('11) considered the tongue-like process or pars 

 tuberalis like the anterior lobe. In the cat, Herring ('08) dis- 

 tinguished, by histological characteristics, a tongue-like process 



