484 B. F. KINGSBURY 
It is not the purpose of this paper to consider the question, in 
how far this conception of the brain plate may assist in the 
understanding of the purely neurologic problem of the structural 
pattern of the brain, but there is much that is suggestive. The 
floor of the midbrain, the ganglion interpedunculare, the corpus 
mammillare particularly, invite examination, while many funda- 
mental structural relations of the vertebrate brain might be 
mentioned whose review from the standpoint here presented 
would be indicated. Inasmuch as other aspects of the broad 
problem of developmental pattern claim the writer’s attention, 
he does not plan, for the present at least, to test further the 
neurological possibilities of the interpretation, even though a 
strong curiosity in the matter prompts thereto. It is hoped, 
however, that the concept may afford a sound basis for neuro- 
logical investigation. 
In closing, I wish to acknowledge the kindness of Prof. 8. H. 
Gage who placed at my disposal the chick and shark embryos’ of 
the collection in his charge, and the helpful codperation of Mr. 
H. B. Adelmann at points where my line of investigation crossed 
with his. 
BIBLIOGRAPHY 
ADELMANN, H.B. 1922 The significance of the prechordal plate: An interpreta- 
tive study. Am. Jour. Anat., vol. 31, no. 1, page 55. 
Baer,C.V.von 1837 UeberEntwickelungsgeschichte der Tiere. Beobachtung 
und Reflexion. II. 
Baurour, F.M. 1881 A treatise on comparative embryology, vol. 2, London. 
Cuitp, C. M. 1921 The origin and development of the nervous system from a 
physiological viewpoint. Univ. of Chicago press. 
Gacs, Mrs. Susanna P. 1905 A three weeks human embryo, with especial 
reference to the brain and the nephric system. Am. Jour. Anat., vol. 
4, pp. 409-443. 
Goronowitscu, N. 1893 Untersuchungen iiber die Entwicklung der sog. 
‘Ganglienleisten’ im Kopfe der Vogelembryonen. Morphol. Jahrbuch, 
Bd. 20, 8S. 187-259. 
6 Many of these series bear evidence of the attention Mrs. 8. P. Gage had 
devoted to the problem of the anterior end of the neural plate. That she had 
definitely rejected as not satisfactory the His plan of arrangement of the zones is 
apparent from her paper of 1905. Doubtless had her health beenspared she would 
have arrived at some alternative explanation, such as that here presented. 
