DEVELOPMENT OF THE LARGE INTESTINE 223 



concludes: ''Als letzten Rest der Driise findet man dann 

 minimale, 0.05-0.15 mm. messende Gruppen kleiner Epithelzellen, 

 die von einer dicken bindegewebigen Kapsel (Fig. 19a) umgeben 

 sind." 



Numerous and distinct lymphoid nodules are present in the 

 vermiform processes of all the embryos from 170 mm. up, but 

 never, so far as I have observed, are the cysts located in them. 

 I agree with Stohr when he says: "Der Verfolg der Serie zeigt 

 immer, dass die reducirten Driisen nur am Rande des Knot- 

 chens liegen, zuweilen sogar in dessen Peripherie hineingepresst 

 sind. Das Centrum der Knotchen enthalt keine reducirten 

 Driisen." 



Moreover, such a degeneration of glands is not found in other 

 portions of the large intestine where lymphoid nodules are plen- 

 tiful. It is not probable, therefore, that the development of 

 lymphoid tissue has anything to do with the formation and 

 degeneration of these cysts. 



There are no marked changes in the form of the mucosa of 

 the vermiform process in the subsequent stages of development. 

 At 240 mm. villi, bulbous glands, and cysts have entirely dis- 

 appeared. The glands, as seen in figure 29, are small and rather 

 widely separated. The muscularis mucosae is distinct and occa- 

 sionally glands can be seen which have pierced it. 



In specimens at seven months, birth, and a two weeks old 

 child, practically the same conditions are found. Lymphoid 

 tissue, both in the diffuse and nodular form, is abundant. The 

 statement made by Berry and Lack ('06) that "In the vermi- 

 form appendix of the full term feotus there is practically no 

 lymphoid tissue, or at least so little as to constitute a negligible 

 quantity, whilst lymphoid follicles are absent," cannot be con- 

 firmed. 



THE AMERICAN JOURNAL OF ANATOMY, VOL. 14, NO. 2 



