6 Franklin P. Mall. 



Cunningham^ ^ confirms fully the conclusions of Eberstaller in 

 the examination of 86 brains of various ages. "At no period in it? 

 growth does the fissure of Kolando exhibit in its position what we 

 might safely regard to be sexual differences." Mingazzini^^ seem 

 to be of different opinion. Eegarding his statement, Waldeyer sounds 

 a warning as follows : "Des weiteren mochte ich herzu noch bemerken, 

 dass es mir, sehr misslich erscheint, Schliisse aus Untersuchungen 

 zu Ziehen, die auf wenige beobachtete Falle sich erstrecken." He 

 further remarks that his own experience agrees with the results <A 

 Eberstaller and of Cunningham. 



It seems to me that it is quite apparent that with the methods 

 used by the above named investigators it cannot be definitely con 

 eluded that there is a marked difference between men and women 

 in the relative amount of brain in front of the central sulcus. The 

 variations in various brains are so great that an approximately cor- 

 rect percentage can only be obtained from a very large number oi 

 specimens and those have been supplied only by Eberstaller and bj 

 Cunningham. Furthermore, the personal equation of the investigatoi 

 plays a very important role in studying a question of this kind, and 

 even if Eberstaller and Cunningham have proved that there is no 

 difference in the position of the central sulcus due to sex, they have 

 not proved that the weight of the frontal lobe does not show such 

 a difference. In fact the methods employed to determine the relative 

 weight of the frontal lobe are so crude that unless the differences 

 found are constant and marked we must challenge the statements 

 of those who assert that differences due to sex exist. I would like 

 to ask them to separate a collection of 100 brains (50 of men and 

 50 of women) each of the same weight and see how well they can 

 do it. Until their "guesses" prove to be correct in over 50 per cent 

 of the specimens examined we must conclude that the "differences," 

 like those of Huschke, are largely due to the personal equation of 

 the investigator. 



^Miile these various attempts, which we consider unsuccessful, 

 have been made to show that there is an unlike distribution of the 



"Cunningham. Jour. Anat. and Physiol., Vol. 25, 1891. 



^Mingazzini. Lezione di Anat. clinica dei centri nervosi. Torino, 1905. 



