438 EDWARD E. WILDMAN 
This is the complete history I believe, of the ‘mitochondria’ 
of Mayer, Romieu, Faure-Fremiet, and Romeis, or the “‘plasto- 
chrondria’ of Meves. Their behavior is such as any inert excre- 
tion grains would and do show in other cells. They undergo no 
division, show no inherent power of growth, and do not trans- 
form into any other substances. They are shifted about in the 
cell by any forces that are set up init. Their staining reactions 
are always those of secretion products, yellow after Benda’s 
stain, and red after Ehrlich-Biondi. They do not take intra 
vitam stains. ° 
DISCUSSION 
Faure-Fremet’s definition of true mitochondria 
It remains only to consider briefly the observations recorded 
in this paper in the light of the study of cytoplasmic inclusions 
in the germ and body cell of other animals, now recognized as 
‘microsomes,’ protoplasmic corpuscle,’ ‘archoplasm,’ ‘mitochon- 
dria,’ ‘ergastoplasm,’ ‘plastochondria,’ and so forth, by various 
authors. The essential point in the study of such inclusions is 
to determine which of them are living, formative elements, and 
which are inert, formed products. 
Ever since the panstaking work of Dujardin, this problem has 
claimed the attention of the most eminent cytologists. Faure- 
Fremiet well says, (page 461, ’10): 
When we find in a cell a fat globule, & vitelline corpuscle or an albu- 
minoid granule which increases in size until it is absorbed or expelled, 
we do not consider this an integral part of the cell, since it results from 
the work of the cell, or it is utilized in this work and does not help to 
direct it. When we see, on the other hand, the nucleus of the cell or 
a leucoplast we consider these as part of the organization of the cell, 
controlling its work. We see them grow and divide like the cell itself, 
and we know that they are active factors in the life of the cell. We 
conclude therefore that the nucleus is a living factor, while ‘the fat 
globule is not. This illustration is clear cut, but it is often far more 
difficult to apply the words formative substance, and formed substance. 
His closing sentence on this subject is of interest in connection 
with this review: ‘‘For my part, when I see that these elements 
divide, that they contain fatty acids, or that yolk material ap- 
