1 82 John Bruce MacCallum, M. D. 



8 cc ""/s CaClg injected into vein of leg. 



Urine secreted in ist lo minutes 2.4 cc 



2d 10 minutes 2.2 " 



3d 10 minutes 1.8 " 



4th 10 mniutes 1.6 " 



5th 10 minutes i-4 " 



10 cc ""/s sodium citrate injected subcutaneously. 



Urine secreted in ist 10 minutes 1.6 " 



2d 10 minutes 2.3 " 



3d 10 mniutes 3.1 " 



4th 10 minutes 3.6 " 



In this case the secretion of urine gradually decreased after the 

 injection of calcium chloride until the amount collected in a unit 

 of time was less than half of the initial amount. The addition of 

 sodium citrate to the blood counteracted this effect so that the 

 rate of secretion again approached the normal. These effects 

 are more striking when the quantity of urine secreted is increased 

 by the introduction of normal salt solution into the blood as shown 

 in the following experiment: 



2. Rabbit — cannula placed in bladder. No urine flowed in 

 the first or second periods of 10 minutes before the NaCl solution 

 was injected. 



Salts other than "Vg NaCl in- Urine in 

 Time. NaCl injected. jected in cc. cc. 



10.10 10 



10.15 10 



10.20 5 0.5 



10.40 10 0.8 



11.00 10 0.5 



11.20 5 i.o 



11.40 10 2.8 



12.00 10 6.0 



12.00 5 cc Vs CaCla intravenously 



12.05 5 cc ^"/s CaClg subcutaneously 



12.20 5 0.2 



12.40 10 1.8 



i.oo 10 0.8 



1 .00 5 cc ^/g sodium citrate intravenously 



1.20 10 2.2 



1.40 5 3.6 



