1 88 John Bruce MacCaUum, M. D. 



12,00 15 ,. 14-4 



12.00 . Yz cc 



12.05 — 



12.10 — 



12.20 — 

 12.30 



12.32 5 cc "Vj 

 12.40 



12.50 5 cc 



1. 00 — 



1. 10 — 



1.20 - 



It will be noticed in this experiment (6) that immediately after 

 the injection of ^ cc. ""/g BaClg solution there is a marked diminu- 

 tion in the flow of urine followed within a few minutes by a very 

 considerable increase. This partial cessation of the flow imme- 

 diately following the injection is due probably to a temporary 

 action of the barium on the muscle coats of the urinary passages. 

 The subsequent increase is the result of the diuretic action of 

 barium on the kidney as described above. 



In considering the actions of calcium and barium we must 

 therefore take into account not only their influence on the glandular 

 tissue, but also their effect on the muscular tissue of the body. 

 In all cases these salts are antagonistic in their action ; and their 

 influence on the secretory activity of the kidney and on the flow 

 of urine is entirely analogous to their influence on the glandular 

 and muscular activities of the intestine. With regard to its action 

 on the kidney calcium chloride may be properly termed an anti- 

 diuretic. 



Attention must be again called to the extremely poisonous nature 

 of barium chloride. A subcutaneous injection of 3 cc 'Vs BaCU 

 solution is usually sufficient to kill a rabbit. Intravenously it 

 should always be injected with four or five times its volume of 

 'Vs NaCl solution. 



CONCLUSIONS. 

 I. In dogs and rabbits the quantity of urine secreted in a unit 

 of time may for a time be markedly diminished and in some cases 

 almost entirely inhibited by the Introduction of calcium chloride 

 into the circulation. 



