xxxviii Journal of Comparati\e Nei^rology. 



paramyoclonus multiplex was described by Friedreich in iSSi, with 

 symptoms such as clonic contractions in a number of symmetrical 

 muscles of the extremities, without affecting the normal coordination 

 and reaction of tnc muscles otherwise. Reflexes were abnormally sen- 

 sitive. A fright or other psychical cause is claimed for the disease, 

 which may be spontaneously self-limited. The author cites a number 

 of very instructive cases showing that it may assume the congenital 

 phase, and apparently succeeds in effecting a differential diagnosis. The 

 prognosis is as unpromising as the therapatliy unsatisfactory. 



RECENT LITERATURE. 



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