No. 1] ORIGIN OF HUMAN MONSTERS. 99 
The embryo of specimen No. 162 is one millimeter long, 
with structures which would make it as old as Eternod’s or 
Graf Spee’s, given in Table I. The chorion is very thin, 
devoid of villi and enveloped in layers of coagulated blood. 
Through this but little nutrition could have come to the em- 
bryo, if it got any at all. The amnion fills the entire chorion 
and its cavity measures 35 x 12 x 12 mm., although the 
whole specimen measures 70 x 30 x 30 mm. According to 
the menstrual history the age of the specimen is at least 
fifty-three days, and if we deduct thirteen days, the age of 
the embryo when it first became affected, then the pathological 
process must have continued during forty days. Sections of 
the embryo show that we are dealing with a remarkable speci- 
men, in which great changes have taken place gradually. All 
of the organs and tissues are dissociated, that is, they have 
grown in an irregular manner, each one growing by itself, 
not being markedly influenced by the surrounding structures. 
The different tissues are not of uniform structure, being 
mucoid in some places and necrotic in others, as is shown in 
the figure. The mucoid tissue runs as a column from the 
heart to the apex of the nodule and may have been derived 
from the chorda dorsalis. At the point of union between the 
amnion and chorion there are three elevations from the em- 
bryo mass into the celom. These are marked in the figure. 
The heart lies within a pocket of its own, which communi- 
cates with the exoccelom and is filled with blood. ‘There are 
also blood-vessels filled with blood in the center of the embryo. 
This interesting specimen of a dissociated embryo, that is, 
one in which the tissues grew in an irregular fashion, is ac- 
companied with another excellent one, No. 250, in which 
these changes are just beginning. In many respects it is 
normal, and for this reason I have also included 1t in Table I 
as an embryo of the fourteenth day. The ovum and decidua 
were curetted from the uterus and came to me opened and 
well preserved. The presence of an excess of magma reticulé 
gave the hint that the specimen was not quite normal. 
The chorion, villi, syncytium and decidua are beautifully 
developed and are normal in structure. Between the villi 
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