124 MALL. [Vou. XIX. 
cord being dilated, while the brain and medulla are solid. In 
these embryos the dissociation is carried to an extreme de- 
gree, the extremities being atrophic, and in some of them the 
embryos are pretty well disintegrated. In Nos. 81, 200 and 
212 the face and the top of the head are composed of a thick- 
ened mass of necrotic tissue, and the changes in the central 
nervous system are extreme. The embryo of specimen No. 
215 is broken into a number of pieces which barely hold 
together. 
Specimens Nos. 142 and 339 are quite typical ones of this 
stage, for in them the dissociation of the tissue is pretty 
complete, and the outlines of the organs are quite obscure. 
Most of the blood has left the blood-vessels and is in the 
surrounding tissues. The fore-brain is completely separated 
from the medulla in No. 339, and in general it is reduced 
“in size: some of it may have escaped through the front 
of the head, which is broken off. The medulla is rounded at 
its free end, is distended and fills most of the head. Had 
this specimen lived it would probably have formed an anen- 
cephalic foetus. But in order to have lived through gestation 
the change in the whole embryo could not have been as radical 
as it is in this specimen, and judging by the anatomy of anen- 
cephalic monsters the destruction of the brain does not, in 
all probability, begin until some time after the sixth week. 
In No. 142 the changes within the embryo are also extreme, 
but the remnants of the organs remain within the body. 
However, the external features of the embryo have van- 
ished entirely, the arms and legs having atrophied completely. 
No. 364, which belongs to this group, is a most remarkable 
specimen, for it forms a typical monster and is accompanied 
by an excellent history. The ovum, covered with a few 
ragged villi, is from a first conception in a woman who had. 
been married four years. It was from a natural abortion, 
the woman being very anxious to have children. In general, 
the woman appears to be healthy, but she has suffered from a 
variety of troubles with her uterus and vagina, which are 
given at greater length in the history of the case. The usual 
