Now r] ORIGIN OF HUMAN MONSTERS. 129 
This infrequency of pathological ova as pregnancy con- 
tinues is not at all remarkable, for human monsters at term 
are not so very common, and while they are produced in the 
early months of pregnancy, at first the changes in them are 
slight, and consequently they are not aborted. The pathological 
ova in which the changes in the embryos are very severe are 
the kind that are aborted and the ones which I have been con- 
sidering. However, the reactions in them give us a hint of 
what takes place in the early stages of monsters that continue 
to develop until the usual end of pregnancy. 
Of the specimens of the seventh week, No. 128 is normal 
in every respect with the exception of the presence of a fairly 
marked magma reticulé in the amniotic cavity. This I 
have not found in other normal specimens, and, since it is the 
earliest and most constant sign of a diseased embryo, it is 
worthy of mention. No. 307 is also no doubt normal, 
although small clumps of leucocytes are found between the 
villi and at points they are found in the mesoderm of the 
chorion. Nos. 268 and 338a may be normal, although some 
tissue changes are seen. These may be due to maceration, for 
the specimens are not especially well preserved. Dissociation 
may have begun in No. 345, but it is more or less obscured by 
the extensive maceration which accompanies it. 
Marked pathological changes are found in specimens Nos. 
320 and 94. In them changes are found in the chorion, show- 
ing that the attack by leucocytes has been very severe. In 
one (No. 94) there is a great amount of granular magma 
within the amnion. The tissues of the embryos are disso- 
ciated, the brain and cord being nearly solid. In general, the 
boundaries of the organs are obscure, their tissues being more 
or less infiltrated with round cells. We have in these two 
embryos conditions found so frequently in younger specimens. 
No. 293 is a specimen of unusual interest, for the sections 
show that most of the embryo is normal, only one portion 
of it being affected. The blister upon the back was 
recognized by Dr. Lamb when he opened the chorion. It is 
filled with a granular albumen, and at its edges burrows into 
