132 MALL. [VoL. XIX. 
A more advanced stage of the conditions found in No. 226 
may be seen in No. 201, which in addition has cyclopia. In 
this specimen there are marked changes within the chorion to 
account for the degeneration of the embryo. The villi of the 
chorion are intermingled in irregular order with blood, fibrin 
and pus, and the mesoderm is fibrous and more or less infil- 
trated with leucocytes and syncytial cells. 
The form of the specimen is that of a younger embryo, 
but the ossification centers of the maxilla, mandible, clavicle 
and humerus are present. The epidermis is nearly com- 
plete, thickened at points, but wanting over the top of the 
head. The mouth and anus are obliterated and the coils of 
intestine form a single mass, into which the entodermal cells 
ramify. In form the thoracic region, vascular system and 
liver are normal, although the cells of the latter are necrotic. 
Throughout the embryo there is an extreme growth of meso- 
dermal tissue, apparently that of the precartilage being the 
most active. This newly-formed tissue seems to have invaded 
the embryonic muscles which are more or less destroyed. 
The changes within the central nervous system are extreme, 
the brain being greatly deformed and separated by a growth 
of connective tissue from the spinal cord below. The cap- 
like process upon the head contains the medulla and mid- 
brain, which are well dissociated, partly necrotic and partlv 
infiltrated with round cells. On either side of this there are 
two degenerated cerebral hemispheres which communicate in 
front of the medulla. The spinal cord begins quite abruptly 
in the upper cervical region, and ends in a marked fibrous 
tumor, one-half millimeter in diameter, in the upper lumbar 
region. In the lumbar and cervical regions the spinal canal 
is filled with mesodermal tissue rich in blood-vessels. Here, 
however, spinal nerves are present, showing that the destruc- 
tion of the spinal cord is of recent date. 
The two eyes form a single hour-glass-shaped body, with 
a double retina, two lenses, a single choroid and a single 
median optic nerve, which does not reach to the brain. Be- 
tween this and the ear and tongue there are a variety of 
