No. 1.] ORIGIN OF HUMAN MONSTERS. 345 
the embryo is to be sought in the chorion, which probably 
failed to attach itself well to the uterus. 
Sections of the chorion show that the villi are far more 
numerous than was suspected from the simple inspection with 
the naked eye. The main wall of the chorion is thin and 
atrophic and is lined with the amnion, which is fully detached 
where it connects with the umbilical cord. However, it must 
have been attached at one time, for remnants of blood-ves- 
sels from the embryo are seen in the villi of the chorion. 
The mesoderm of the villi is very fibrous and the villi are 
matted together by a slimy mass rich in blood and leucocytes 
with fragmented nuclei. The syncytium is well developed 
and extends into the mass of blood and slime. The decidua 
over the chorion has large sinuses within its walls, is quite 
hemorrhagic and at points has large islands of leucocytes, 
usually situated along the course of the blood-vessels. 
The photographs show the condition of the embryo. Hare- 
lip, displaced ears, protruding viscera in front and spina bifida 
behind. The large blood-vessels and heart are still filled with 
blood and there is quite a general infiltration of the tissues 
with round cells. The vessels of the embryo end in the cord 
and do not reach to the chorion. In general, there is mainly 
a destruction of the tissues due to the irregular growth of the 
embryo. 
The central nervous system has been converted, in great 
part, into a mass of connective tissue, with remnants of the 
cord below and a rudimentary brain above, which forms a 
shield upon the protruding mass. A portion of this shield 
has grown into the connective tissue below, forming a gland- 
like structure. 
The clavicle, mandible and maxilla have begun to ossify 
and some of the muscles are well developed. 
No. 365. 
Embryo, 14 mm. 
Professor Pohlman, Bloomington, Ind. 
This embryo, with spina bifida, iniencephaly and anenceph- 
alus, and extremities of normal form, has a straight body 
