162 EAYMOND PEARL 



2. A detailed account of the breeding of the stock used, prior 

 to the beginning of these experiments, is given. It is shown to 

 be inbred to only a comparatively low degree. It is shown to be 

 a random sample of the general population from which it came. 

 Full brothers and sisters of treated are used as controls. 



3. The poisons used were administered daily by the inhalation 

 method in practically as large doses as could be tolerated when 

 given in this way. An account of the methods used and the 

 precautions taken to ensure critical results will be found on 

 pp. 132-138. 



4. The total germ dosage index, defined as the total number 

 of days to which the gametes forming zygotes had been exposed 

 to treatment when the offspring were produced, ranged from 

 130 to 354 days in these experiments, with a mean of 210.35 

 days, or approximately 7 months. 



The results of these experiments will be presented in the two 

 next following papers in this series. Those two papers and the 

 present one (Nos. I, II, and III in the series) deal with the re- 

 sults from the beginning of the alcohol experiments in Septem- 

 ber, 1914 up to February 1, 1916. Later reports will deal with 

 the results after the latter date. 



IV. LITERATURE CITED 



(1) Basile, C. 1908 Influenza della lecitina sulla determinazione del sesso e 



sui caratteri Mendeliani. Rend. R. Ace. dei Lincei. CI. Sci. fis. ecc, 

 vol. 17, ser. 5 a, pp. 643-652. 



(2) Ceni, C. 1904 Influenza dell'alcoolismo sui potere di proereare e sui 



discendenti. Riv. sper. di Freniatria, vol. 30, pp. 339-353. 



(3) Cole, L. J. and Bachhuber, L. J. 1914 The effect of lead on the germ 



cells of the male rabhit and fowl as indicated by their progeny. Proc. 

 Soc. Exp. Biol. Med., vol. 12, pp. 24-29. 



(4) Cole, L. J. and Davis, C. L. 1914 The effect of alcohol on the male 



germ cells, studied by means of double matings. Science, N. S., vol. 

 39, pp. 476^77. 



(5) Czapek, F. 1905 Biochemie der Pflanzen, Zweiter Band. Jena, pp. xii + 



1026. 



(6) East, E. M. and Hayes, H. K. 1912 Heterozygosis in evolution and in 



plant breeding. U. S. Dept. Agr. Pur. Plant Ind. Bulletin 243, pp. 

 1-58. 



(7) Elderton, E. M. and Pearson, K. 1910 A first study of the influence of 



parental alcoholism on the physique and ability of the offspring. Eu- 

 genic Lab. Mem. X, (London), pp. 1-46. (Second edit.) 



