author's abstract of this paper issued 

 by the bibliographic service march 2 



STUDIES ON CYTOLYSINS 



I. SOME PRENATAL EFFECTS OF LENS ANTIBODIES 



M. F. GUYER AND E. A. SMITH 



From the Zoological Laboratory, University of Wisconsin 



1. INTRODUCTION 



Ever since the pioneer work of Buchner in 1889 and of Beh- 

 ring and Katasato in 1890, there has been a lively interest in the 

 subject of so-called immune sera. The last few years have 

 brought forth a flood of literature on antitoxins, agglutinins, 

 precipitins, bacteriolysins, hemolysins, cytotoxins or cytoly- 

 sins, and opsonins — all the fruition of these earlier investigations. 



Inasmuch as the first discoveries were concerned with certain 

 bactericidal properties artificially produced in the sera of ani- 

 mals through the injection of various species of bacteria, and 

 because of the tremendous importance of these facts in furthering 

 our knowledge of infection and immunity, the field became at 

 once the province of the bacteriologist and the pathologist. 

 Following closely upon the heels of the earlier discoveries came 

 a brilliant series of practical apphcations in diagnosis, prophy- 

 laxis, and therapeutics, until it is not to be wondered at that 

 investigators became absorbed in the medical phases of the 

 subject. It is clear, however, that the phenomena in question 

 all have their broader biological aspects, and it seems time 7~o 

 see if the knowledge already gained in this field may not be 

 utilized in a new attack upon certain fundamental biological 

 problems. 



The work already done on precipitins, in fact, shows how these 

 methods may be applied. When "rabbits are injected with several 

 doses of serum prepared from horse-blood, for example, their 

 blood develops a substance not present in the blood of untreated 



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THE JOURNAL OF EXPERIMENTAL ZOOLOGY, VOL. 26, NO. 1 



