author's abstract of this paper issued 

 by the bibliographic service march 30 



ON SEVERAL EFFECTS OF FEEDING SMALL QUANTI- 

 TIES OF SUDAN III TO YOUNG ALBINO RATS^ 



S. HATAI 

 From The Wistar Institute of Anatomy and Biology 



THREE CHARTS 



Daddi's ('96) observations on rabbits, guinea-pigs, and fowls 

 which showed that Sudan III mixed in oil is readily absorbed from 

 the alimentary tract, and is ultimately deposited in the adipose 

 tissue, induced numerous investigators to study the problem of 

 the metabolism of fat by the use of this dyestuff. Recently 

 Ehrlich and his pupils demonstrated that certain dyestuffs can 

 stain some micro-organisms in vivo, and indeed in some instances 

 such chemical substances thus introduced into the animal body 

 produce a curative effect. This new line of investigation, now 

 called ' chemo-therapy, ' induced numerous investigators to ex- 

 amine the possible affinities between organisms and various dye- 

 stuffs, including Sudan III, and consequently the literature on the 

 feeding of Sudan III is quite large. I shall therefore review 

 only a few studies which are intimately concerned with my own 

 experiments. 



Riddle ('08) fed Sudan III to hens during the laying period, 

 and demonstrated that this dyestuff is easily absorbed into the 

 egg and the yolk fat intensely stained. 



In another paper. Riddle ('10) gives further observations on 

 •feeding Sudan III to domestic fowls, and not only extends his 



1 This research was closed and set aside in January, 1916, because it had not 

 given the information originally sought, and the further study of the atrophy 

 of the thymus and other viscera did not fall within our program. The problem 

 of the changes in the thymus has now been taken up by Dr. Ivan Wallin, and in 

 view of the fact that the work is to be carried on, it has seemed proper to pub- 

 lish the results already in hand.— S. H. 



101 



