authors' abstract op this paper issued 

 bt the bibliographic service, march 2 



FURTHER STUDIES ON THE MODIFICATION OF THE 



GERM-CELLS IN MAMMALS: THE EFFECT OF 



ALCOHOL ON TREATED GUINEA-PIGS 



AND THEIR DESCENDANTS 



CHARLES R. STOCKARD AND GEORGE N. PAPANICOLAOU 



From the Departmeid of Anatomy, Cornell Medical School, New York Citii 



NINE FIGURES 



CONTENTS 



1. Introduction 120 



2. Quality of the experimented and control animals 123 



a. Selection of animals 123 



b. Inbreeding 124 



c. The number of animals alcoholized 125 



3. Experimental method and the care of animals 127 



4. The influence of alcohol inhalation on the individual 130 



a. Contrast between the immediate effects of alcohol taken by inha- 



lation and by stomach 132 



b. The vigorous condition of the animal after daily inhalation of alco- 



hol for long periods 133 



5. A general comparison of the progeny from alcoholic lines with those 



from normal lines 142 



6. Absorption of embryos in utero and abortions of parts of litters: methods 



of detecting these processes 156 



7. A comparison of the qualities in the different generations of the alco- 



holic lines as they become further removed from the generation di- 

 rectly treated 159 



8. A comparison of animals from directly treated fathers and fathers of 



alcoholic stock with animals from directly treated mothers and 

 mothers of alcoholic stock and with others from both parents of 

 alcoholic stock, 168 



9. A comparison of lines from only male ancestors alcoholic with lines 



from only female ancestors alcoholic and with those from both male 

 and female ancestors alcoholic 176 



10. Treating males with alcohol for one and two generations compared with 



treating females for one and two generations 183 



11. The sex-ratio in relation to paternal and maternal alcoholism and to 



the treatment of male and female ancestors with alcohol 187 



119 



