140 CHARLES R. STOCKARD AND GEORGE N. PAPANICOLAOU 



experiment weighed respectively, 822, 635, and 527 grams, the 

 female being old and the two males young growing specimens. 



They were each given about 20 cc. of 15 per cent ethyl alco- 

 hol in tap water daily, except that once each week they were 

 given almost 30 cc, which was a completely intoxicating dose. 

 The 20-cc. dose causes all of them to be groggy for a few hours 

 after drinking it; the effect increases for an hour or so and then 

 gradually wears off. There is only slight if any change in rectal 

 temperature. The animals seem fully recovered on the follow- 

 ing day and have a normal appetite, but do not eat so ravenously 

 as do untreated individuals. 



When 30 cc. of 15 per cent alcohol is given in three 10-cc. 

 doses at fifteen-minute intervals the animal is badly intoxicated 

 and unable to walk within fifteen or tw^enty minutes after the 

 last dose. The hind legs are particularly uncertain, the animal 

 often tumbling over almost on its back, kicking frantically and 

 having great difficulty in righting itself. Should its mouth come 

 in contact with food the guinea-pig will chew in a peculiar man- 

 ner, seeming in all reactions to be typically drunk. After one 

 and a half or two hours the animal lies on its side with its trunk 

 muscles often undergoing spasmodic contractions several times 

 per minute, if taken up or made to move it struggles and falls 

 panting in the drunken condition. By this time the body tem- 

 perature may have fallen as much as 2 degrees below the pre- 

 treatment record. After three hours it is still unable to stand 

 or walk and is breathing hea^41y with a temperature as much as 

 2^ degrees Fahrenheit below^ normal. After four hours the con- 

 dition is about the same and so for several hours longer until it 

 gradually begins to recover and by the following morning it is 

 fully recovered, but shows in its appearance the effects of the 

 experience of the previous day. 



When animals are given five partial and one complete intoxi- 

 cation by stomach alcohol per week they begin after a few days 

 to regurgitate some of the stomach contents on receiving the 

 first swallow or so of alcohol, but after this they take the dose 

 without further disturbance, though they resist taking it more 

 and more each time. Their desire for food is somewhat reduced 

 as the treatment is continued. 



