162 CHARLES R. STOCKARD AND GEORGE N. PAPANICOLAOU 



the same as in the total alcoholic column, 34.6 per cent of the 

 animals were born in litters of less than three and only 17.74 

 per cent in litters of more than three. The normal record as 

 pointed out before is just about the reverse of this. The average- 

 size litter in which the Fi animals occur is 2.51, which is slightly 

 larger than for the total alcoholic column, but the average 

 weight of these litters is less than for the entire alcoholic lines, 

 being 165 against 170 grams. As compared with the control the 

 average productivity of this column is 32 grams low, and when 

 corrected on the basis of the average-litter size, the litters are 

 then more than 13 grams less than the control standard. The 

 mating failures are about the average alcoholic result, 12.94 

 per cent. 



The mortality record of the Fi animals is not so good as for. 

 the entire alcoholic group, only 56.98 per cent of them living 

 longer than three months as against 64.47 per cent. The total 

 mortality is 43.01 per cent, and when this is corrected on the 

 basis of the normal mortality for the various-size litters in which 

 the individuals occurred, we find that the Fi mortality is almost 

 2.3 times the control record, or 230 against 100. The corrected 

 mortality here as compared with the entire alcoholic group is 

 230 against 189, or 41 points higher. 



The proportion of prenatal to postnatal mortality corre- 

 sponds closely to that of the entire alcoholic group and contrasts 

 with the control in the same way as discussed in considering 

 table 1. 



Finally, then, the Fi group of animals from either one or both 

 treated parents, are inferior to the alcoholic group as a whole in 

 having a higher mortality record and in occurring in litters of a 

 lower average weight although of equal average size. 



The fourth column contains the records of animals more than 

 one generation distant from the alcohol treatment; that is, those 

 having treated grandparents, great-grandparents, or great-great- 

 grandparents, or combinations of these, F2, F3, and F4 generations. 

 All of the alcoholic animals from column 2 are included in this 

 column, except the third column of Fi animals; there are thus 

 408 individuals. 



