ie Helen Dean King. 
granular at this time, elsewhere it contains numerous rounded 
granules, staiming very intensely, that are much smaller than the 
nucleoli and many times larger than the minute granules which 
normally form the karyoplasm. In a later stage (Fig. 21) the 
nucleus is filled with numerous short fibres composed of deeply stain- 
ing, rounded granules which appear similar to those scattered through 
the nucleus at the stage of Fig. 20. There is no finely granular 
karyoplasm anywhere in the nucleus at this time, and the fibres, 
as well as the remaining nucleoli, lie in an apparently fluid space. 
The immense number of the large granules in the nucleus at this 
stage of degeneration seems to preclude the possibility that these 
bodies have been derived from chromatin or from the substance of 
the relatively few nucleoli that have been dissolved. It seems prob- 
able, therefore, that these granules have originated from the granular 
karyoplasm, since their number increases in proportion as the minute 
karyoplasmic granules disappear. At the stage of Fig. 21 follicle 
cells and blood capillaries are beginning to enter the cytoplasm of the 
cells to complete the processes of disintegration and absorption. The 
nuclear membrane breaks down at or soon after the stage shown in 
Fig. 21, and the nuclear contents come in direct contact with the 
cytoplasm. Unfortunately the rudimentary ovaries contain no later 
stages in the degeneration of the large ova. 
The granular fibres which fill the greater part of the nucleus at 
the stage of degeneration shown in Fig. 21, bear a very striking 
resemblance to the “oxychromatin” fibres found in connection with 
the nucleoli during the early post-synizesis stages in the development 
of the young odcytes. It is possible, therefore, that the latter struc- | 
tures are not composed of chromatin but of fused karyoplasmic 
granules which have great affinity for the chromatin stains. If this 
interpretation is correct, then the chromatin in the amphibian egg 
is probably not concerned in any way with the formation of the 
nucleoli which are doubtless waste products of nuclear metabolism. 
Cerruti, ’07, has recently given a brief description of two cases 
of hermaphroditism which he has found in Bufo vulgaris. In one 
individual the anterior part of each testis had developed into a small 
rudimentary ovary lying between Bidder’s organ and the testis proper: 
