On the Histogenesis of Gastric Glands. 495 
picture as varied as that of all other parts of the stomach together, 
including within its limits all types of glandular development 
found at these stages in the stomach. It is thus defined by its 
gross boundaries, rather than by any well marked histologic or 
glandular type. By 7 cm. the rugae and papillae have by the suc- . 
cessive appearance of smaller ones on the larger, acquired com- 
plex, fantastical shapes, like those seen in a papilloma. The 
comparatively few glands appear both on these rugae and in 
the depressions between them. Some of them have progressed 
to the stages of Figs. 6 and 11, and hence resemble the pyloric 
glands in size and form, but have developed some parietal cells. 
Mucus cells appear, for the first, in the 6—6.5 cm. stomach, at 
which time all the cells in the lesser curve (pyloric) area stain 
very definitely and deeply with muchematin. In general, the 
surface cells and those near the top of the gland have but a 
shallow, distal rim of mucus, the rest of the cytoplasm being of 
the ordinary, granular type. In the deep cells of the tubules, the 
cytoplasm distal to the ovoid nucleus is of alveolar structure, the 
alveoli being filled with mucin. If care is taken to preserve the 
tissue from the action of water, the mucus occurs in the form of 
spherules, one in each alveolus (fig. 12), and enclosed by the slen- 
der alveolar wall. With the three color, or hematoxylin and eosin 
stain, the cytoplasmic part of these cells, surrounding the nucleus, 
and in the first mentioned type, occupying the whole cell except 
the distal rim, presents the ordinary, finely granular, slightly 
reddish appearance of the ordinary embryonic cells; the mucus 
part appears clear, and has an alveolar network. In the other 
parts of the pylorus (greater curve and facies anterior and pos- 
terior) no mucus cells have appeared, all the cells being of the 
primitive type. As to size and form, the glands are uniform in 
all parts of the pylorus. 
At 7 cm. the region from C to 4 (fig. 10) represents the terri- 
tory of the adult cardia and fundus. There is a gradual and pro- 
gressive increase from C to 4 in the age of the glands. Those 
toward C are in the intraepithelial stage (fig. 3). They occur 
clear up to the caecal ridge, where the epithelium becomes 
level. Toward 4 the glands approach the type of fig. 7, but are 
