154 CARL R. MOORE 



is not an especially marked increase in the quantity of interstitial 

 cells as has been described by some writers. It is true that the 

 tubules are quite widely separated and the intertubular spaces 

 are occupied by cells, but there has been a very considerable 

 invasion of connective tissue as well as an abundance of the cells 

 to which particular attention was directed. 



V. SPECIFIC CONSIDERATIONS OF INDIVIDUAL GRAFTS 



A. The ovary 



Included in this section are the more specific details of the 

 histology of the individual grafts of ovaries recovered from the 

 male animals into which the transplantation had been made 

 at an earlier date. 



Animal 40-4 A2B2 II (table 1). Male rat, born Nov. 14, '17. Dec. 

 17, the left testicle was removed, and two small pieces of ovary from a 

 sister were grafted subcutaneously. May 18, '18, animal killed; left 

 testis is normal, sperm sacs are normal; one ovarian graft quite promi- 

 nent, the second one small ; the largest graft was sectioned for study. 



Microscopic. The principal part of the persisting graft is 

 made up of sections of the oviduct which was carried along with 

 the piece of ovary at the time of transplantation; the ovarian 

 tissue proper is very small in amount, since it is present in only 

 about fifty sections (10/x thick). The ovarian tissue proper is 

 so small in amount that in some sections the one large normal 

 Graafian follicle appears not to be surrounded by ovarian stroma. 

 However, close examination shows a small amount of encapsu- 

 lating stroma tissue, and to one side of the large follicle 

 are a number of atretic follicles of very small size. There is 

 little of especial interest in the small abnormal follicles, but there 

 is considerable interest associated with the apparently normal 

 follicle evidently very close to the stage of maturation. The 

 stratum granulosum is normal in appearance, the thecal layers 

 of the follicle are normal; there is a large follicular cavity and 

 the ovum appears absolutely normal and possesses a well-marked 

 normally staining nucleus; the ovum is surrounded by the discus 

 proligerus in an entirely normal manner, and in short, the follicle 



