PHYSIOLOGICAL PROPERTIES OF GONADS 155 



is apparently perfectly normal in spite of the fact that so little 

 ovarian tissue is present that in places scarcely any stroma tissue 

 is apparent at the peripheral margins of the follicle. 



In this graft there has been apparently a large amount of 

 resorption and in the sections studied there are abundant evi- 

 dences of inflammatory changes having taken place. The cavity 

 of the fallopian tube shows masses of leucocytes throughout the 

 entire 200 sections (the ovarian tissue proper is present in only 

 about fifty sections) and within the Ijmiph spaces of the oviduct 

 and areolar tissue surrounding the ovarian tissue there is a great 

 amount of lymphocyte infiltration. Evidently, associated with 

 the inflammation and the small amount of stromal tissue, there 

 has been a considerable amount of destructive changes, possibly 

 an infection of the graft, that has resulted in a degeneration of 

 part of the graft; but the remarkable thing is that there can be 

 such a normal, well-developed follicle at such a late stage of 

 formation in the small amount of ovarian tissue that has per- 

 sisted throughout the entire 152 days of residence of the graft 

 in the male animal. This indicates a comparatively great 

 resistance on the part of the follicle and contents rather than an 

 extremely non-resistant condition, as held by Foa. There are 

 no evidences of lutein tissue or of ovulation in this graft. 



Animal 40-4 A2B2 IV. Male rat, born Nov. 14, '18. Dec. 18, left 

 testis removed, two small pieces of ovary from sister grafted subcu- 

 taneously. May 18, '19, animal killed; right testis is normal, sperm 

 sacs normal, both grafts had persisted; one was sectioned. 



Microscopic findings. The ovarian graft recovered 152 days 

 after implantation in- the male rat, one of whose testes had 

 remained in position, is of considerable size and perfectly normal 

 histologically. Figure 1 shows a section of the graft which is 

 surrounded by a muscular and fibrous capsule. The original 

 peritoneal sac covering the ovum has been retained and provides 

 a sac-like covering for the graft in such a way that the cortex 

 does not come in contact with other tissues. Both medulla 

 and cortex are distinct, including the very large number of follicles 

 of all stages of development situated in the latter. A section of 



