156 CARL R. MOORE 



the oviduct accompanies the graft, having been carried along 

 with the ovary at the time of transplantation. 



The graft proper, cut lO/j. in thickness, consists of 360 sections. 

 Graafian follicles can be seen in any section of the gland, and 

 these represent all stages of development from the primordial 

 to the mature follicle. The younger ones consist of a very 

 small ovum surrounded by a single layer of follicular cells; older 

 ones are surrounded by a greater number of cells and may show 

 just the beginning of formation of a cavity, while still others 

 contain a follicular cavity of larger size; still older follicles show 

 a very large follicular cavity containing the ovum surrounded 

 by the discus proligerus, the whole follicle being in a stage of, 

 or very near, maturity. All gradations of atretic follicles are 

 likewise present from stages showing the beginning fragmen- 

 tation of the ovum, through larger atretic follicles containing 

 no evidence of an ovum, to small atretic ones, in some of which 

 only the suggestion of the remains of the old follicular cavity 

 can be made out. There is such a close gradation that many 

 times it is difficult to say whether the region represents an atretic 

 follicle or simply the large reticular, interstitial cells of the stroma. 



In this graft seventy normal follicles have been counted; 

 these represent all stages of development and all contain the 

 ovum possessing a distinct and well-stained nucleus. The 

 atretic follicles are so numerous and many times it is so difficult 

 to call the structures follicular masses or interstitial cells, that 

 no attempt has been made to enumerate them. There is an 

 abundance of very young follicles situated just within the periph- 

 ery of the graft, many of them containing normal ova; others, 

 however, perfectly distinct as follicles, show absolutely no traces 

 of an ovum. Within the granulosa cells of the larger follicles 

 a great number of karyokenetic figures indicate that the follicles 

 are growing in a perfectly normal fashion and dispel the idea 

 that they are only persisting follicles at the same stage as when 

 the graft was made. 



There is considerable evidence of new follicle formation about 

 the periphery of the graft for certain regions show the presence 

 of perfectly evident follicles, with or without an ovum, but the 



