158 CARL R. MOORE 



follicles containing normal-appearing ova with distinct and well- 

 stained nuclei have been studied, besides numerous atretic 

 follicles containing ova in which there is a spindle bearing perfectly 

 distinct chromosomes, ova that are not surrounded by a discus 

 proligerus, but are free within the follicular cavity and under- 

 going fragmentation, as well as all stages of degeneration of the 

 follicle and its conversion into interstitial tissue. Figures 3, 

 4, 5, 7, 8, and 11, all from this graft, represent the development 

 of a follicle and the fate of the follicles undergoing atresia. 

 Figures 7 and 8 show atretic follicles containing an ovum with a 

 mitotic spindle or fragments of the ovum. 



There is an abundance of very small follicles (primordial 

 follicles) with or without ova, but there is no evidence of a corpus 

 luteum or of ovulation. 



Testis. The remaining testicle of this male, which had been 

 functioning as a male, is perfectly normal. A section of it is 

 shown in figure 15 and it warrants no further consideration. 



Animal 49 C. Male rat, born Nov. 6, '17. Dec. 3, the right testis 

 was removed, and two pieces of ovary from sister placed subcutaneously. 

 Aug. 22, '18, animal killed, the left testis was normal, and both ovary 

 grafts had persisted for the period of 230 days; both grafts sectioned. 



Graft 1. This graft, the smaller of the two, consists of about 

 165 sections; cortex and medulla are distinct and between sixteen 

 and twenty follicles containing well-defined ova surrounded by 

 the discus proligerus and containing a well-stained nucleus have 

 been studied. These follicles represent all stages of develop- 

 ment from the primordial follicle to the follicle ready for ovula- 

 tion. Scores of atretic folHcles of all sizes are present; these 

 comprise follicles with fragmenting ova, follicles whose con- 

 tained ovum appears normal, but in which the discus proligerus 

 has undergone partial or almost complete dissolution, and smaller- 

 sized follicles that are distinctly surrounded by a fibrous-like 

 connective tissue, but whose granulosa cells are enlarged and 

 show the loose reticular cytoplasm characteristic of the cells 

 containing considerable lipoid materials and in which there is 

 either a well-defined follicular cavity, a very small cavity, or 

 again masses of the same character in which no cavity is dis- 



