160 GAEL R. MOORE 



occurred and it seems possible, in the absence of other indications, 

 to suppose this a case of corpus luteum formation without ovula- 

 tion; and if this assumption is correct, evidently the cells of the 

 granulosa layer have been converted into the cells of the corpus 

 luteum. This idea is not without a parallel, for evidences of 

 somewhat similar conditions have been reported (see work of 

 Rasmussen and Corner) . 



Graft no. 2 presents nothing worthy of comment except its 

 small size (about forty-five sections of ovarian tissue) and the 

 presence of a comparatively large number of follicles most of 

 which are small in size, and the majority of them atretic. 



Animal 51 E. Male rat, born Feb. 27, '18. Apr. 13, one testis 

 removed and two pieces of ovary from sister placed subcutaneous^ and 

 intraperitoneally. Aug. 22, '18, killed; remaining testis normal; both 

 grafts persisted for the 130 days; both grafts sectioned. 



Graft 1. The tissue of this graft proves to be only a mass of 

 the oviduct; several sections in one plane show that it has been 

 greatly coiled. Practically the entire mass of ovarian tissue has 

 been resorbed. 



Graft 2. This graft has been well preserved and consists of 

 about 290 sections of ovarian tissue. Medulla and cortex are 

 distinct and fifty-five normal follicles have beqn studied (follicles 

 3ontaining a normal-appearing ovum with a distinct and well- 

 stained nucleus) ; besides the normal follicles there are literally 

 hundreds of follicles that are in a stage of atresia. These atretic 

 follicles may contain ova showing a distinct spindle with chromo- 

 somes arranged equatorially, ova that have undergone fragmen- 

 tation, or the follicle may contain no ovum at all, but yet show 

 a distinct and large follicular cavity lined by an uninterrupted 

 granulosa layer of several cells deep ; or the cavity may be small 

 with a distinct granulosa layer, the cells of which have been 

 changed to the large lipoid cells; or yet the cavity may have been 

 entirely obliterated, but the large lipoid cells are a distinct mass 

 and are surrounded by the fibrous layer that represents the old 

 theca externa, the mass now being regarded as interstitial cells. 



Figure 2 is a section of this graft and the relative number of 

 atretic follicles to normal ones is clearly shown; a and b are 



