PHYSIOLOGICAL PROPERTIES OF GONADS 163 



Steinach's material there was an apparent hypertrophy rather 

 than a real one; had the entire mass of interstitial cells of the 

 original testis been concentrated into such a small mass as would 

 have remained after degeneration of the germinal epithelium, 

 they would have appeared in considerably more concentrated 

 masses than in the normal condition. 



Animal 40-4 A2B2 V. Female, born Nov. 14, 1917. Dec. 17, 

 right ovary removed, two testis grafts placed subcutaneously. Sept. 

 2, '18, killed; left ovary normal, both testis grafts had persisted (this 

 female gave birth to a litter of five on May 10). Grafts were not 

 sectioned. 



Animal 49 B. Female, born Nov. 6, 1917. Dec. 1, right ovary 

 removed and two pieces of testis from brother rat placed subcutane- 

 ously. Aug. 22, '18, animal killed; left ovary normal, both testis grafts 

 had persisted, good vascularity in both. Both grafts sectioned, as 

 well as ovary. 



Graft 1 consists of a very considerable mass of typically 

 degenerated seminiferous tubules and interstitial material. 

 Figure 14 is a high-power drawing of a small part of one section, 

 and shows five or six tubules in cross-section with the accom- 

 panying interstitial material between the tubules. It can 

 readily be noted that the tubules are not normal, but that during 

 their residence in the female host the germinal epithelium has 

 suffered destruction; all that remains within the tubules of a 

 cellular nature are the large cells lying close to the basement 

 membrane and considered as the Sertoli cells. 



Graft 2, in comparison with the preceding one, is smaller in 

 size, but the tissue presents no new features worthy of note. 

 Seminiferous tubules are present in 200 or more sections of the 

 graft tissue and these are well rounded and show but little 

 tendency to collapse. The entire mass of the graft is surrounded 

 by muscle tissue. 



Sections of the remaining ovary of this animal show it to be 

 entirely normal, though the animal had never given birth to a 

 litter. 



Animal 51 A. Female, born Feb. 27, '18. April 16, one ovary 

 removed, testis from brother implanted subcutaneously and intra- 

 peritoneally. Aug. 22, '18, killed; right ovary normal, small intra- 



