PHYSIOLOGICAL PROPERTIES OF GONADS 169 



VII. SUMMARY AND CONCLUSIONS 



1. In the rat, an ovary grafted into a male animal, possessing 

 one normal testicle, will become vascularized and grow for at 

 least eight and one-half months after the transplantation. 



2. The graft, after remaining in the male for this relatively 

 great length of time, possesses all the characteristic structures 

 of the ovary excepting the corpora lutea. 



3. The characteristic growth of graafian follicles continues in 

 a perfectly normal way up to about the stage of maturation; 

 from this time on the history of the follicle is abnormal. 



4. From about the stage of maturation the follicles undergo 

 atresia, the ovum fragments and disappears, and the cells of the 

 stratum granulosum are converted into interstitial cell masses. 



5. The large ovarian grafts, containing all the characteristic 

 structures of the ovary excepting the corpus luteum, have given 

 no evidence of a deleterious influence upon the male somatic or 

 psychical characteristics. 



6. Pieces of testis grafted into a female animal, possessing one 

 ovary, persist at least eight months. 



7. The seminiferous tubules, as in most cases of testis grafts, 

 are present, well rounded, but contain only Sertoli cells; the 

 germinal epithelium has undergone degeneration. 



8. The presence of the testicular grafts has no deleterious 

 influence upon the somatic or psychical characteristics of the 

 female animal. 



9. There is no indication of an antagonism between the ovary 

 or testis, even when existing in the same animal in a functional 

 condition. 



10. These experiments afford direct evidence of the physio- 

 logical possibility of a functional hermaphroditic condition in 

 mammals. 



May 1, 1920. 



