374 GAEL R. MOORE 



Transplantation of ovaries into this male animal was so suc- 

 cessful that the ovaries grew, could be easily palpated, and their 

 position noted by a slight elevation of the skin over the site of 

 the growing graft. Associated with the presence of the grafts, 

 as in the preceding cases, teats had developed into large, well- 

 rounded structures as large as those of pregnant females. The 

 animal was tested periodically as in the cases already described, 

 and the results were the same as those with the other ovarian 

 grafted males. The animal, though possessing well-developed 

 teats and the two large grafts, retained its male psychical char- 

 acteristics throughout the entire period of the observations. It 

 would follow the females, uttering the male call and otherwise 

 behaved as a typical male. And, as in the former cases, the ani- 

 mal exhibited no maternal or feminine instincts throughout its en- 

 tire life; it would fight away young ones that attempt to suckle it. 



At the time of killing, the teats of the mammary glands were 

 very prominent ; the grafts were recovered from their original site 

 of implantation and preserved in Bouin's fluid. 



Both of the ovarian grafts had persisted for the seven months 

 after transplantation, but histological sections show that the small- 

 er of the grafts consists largely of fimbria of the oviduct. There 

 was but little ovarian stroma or included cells (considered as 

 interstitial cells) in the graft and no normal Graafian follicles were 

 observed. 



The larger graft consisted of characteristic ovarian tissue as 

 well as a small part of the oviduct and fimbria. The peritoneal 

 capsule that normally surrounds the ovary had been removed 

 during the process of transplantation, and in so far as the epi- 

 thelial covering of the ovary was not protected from the 

 tissues of the host, the tissue of the ovary grades almost imper- 

 ceptibly into the surrounding connective tissue and muscle. 



There were more than 500 sections of the graft that contained 

 typical ovarian tissue (cut lO/x thickness). Within this tissue 

 are many Graafian follicles, some undergoing atresia and others 

 that are normal. The normal follicles are young ones (primordial 

 follicles) or older ones that show a typical follicular cavity, and 

 all other elements of the normal follicle in the usual relation. 



