HYPOPHYSIS CEREBRI OF CALIFORNIA GROUND-SQUIRREL 195 



richer in acidophile matter the larger the cell, although this is 

 not accurately determinable from the fact that many of the 

 poorly granular cells have ill-defined margins. The nuclei of the 

 chromophobes usually lie centrally. From the fact that the 

 nuclei of these cells seem entirely intact under practically all 

 conditions and show no signs of nuclear degeneration, it is prob- 

 able that they are not degenerated, as some have suggested, but 

 that they are in the early stages of accumulating granular matter. 

 The nuclei of the chromophiles usually lie eccentrically, being 

 located in that part of the cells most distant from the vascular 

 sinuses upon which they border. 



Fig. 4 (a) From the pars distalis showing the border-cells on the lumen. 

 X 1200. (b) From the pars infundibularis showing the border cells with their 

 extensions into the gland substance. In both (a) and (b) the border cells appear 

 darkened. X 1200. 



Figure 5 gives an example of the two extremes — one markedly 

 chromophilic, a, and the other chromophobic, b. The cell outlines 

 of the chromophobes are not usually so distinct as shown in b. 

 While the two cell types here figured were adjacent in the prepa- 

 ration, the more common arrangement is to find various inter- 

 mediate forms commingled with these, figure 7 showing such a 

 group in one of the alveoli. It is important to bear in mind that, 

 while the two extremes are less sharply set apart, there are, 

 nevertheless, just as strongly chromophilic and chromophobic 

 cells in the ground-squirrel hypophysis as in other forms. 



When stained with orange G and acid fuchsin, according to Scaf- 

 fidi's technic, there were seen in sections, cells staining deeply with 



