AUTHOR S ABSTRACT OF THIS PAPER ISSUED 

 BY THE BIBLIOGRAPHIC SERVICE, OCTOBER 27 



THE ORIGIN, GROWTH AND FATE OF OSTEOCLASTS 

 AND THEIR RELATION TO BONE RESORPTION l 



LESLIE B. AREY 



Anatomical Laboratory of the Northwestern University Medical School 



TWENTY-FOUR FIGURES (FOUR PLATES) 



CONTENTS 



Introduction 315 



Historical 316 



Origin 316 



Multinuclearity 318 



Fate 319 



Material 320 



Observations 321 



Discussion 328 



Summary 334 



Bibliography 335 



INTRODUCTION 



Robin ('49) appears to have been the first to distinguish 

 clearly between the giant-cells of bone marrow (megakaryocytes) 

 and those associated, with bone itself (polykaryocytes), although 

 it is probable that F. Bidder ('43) appreciated some such 

 distinction. 



Due chiefly to the efforts of Kolliker ('73), the multinucleate 

 cells of developing bone are known as 'osteoclasts' and are 

 regarded commonly as the direct agents of bone resorption. 



The present communication comprises a report of certain 

 observations made during the last three years upon the origin, 

 growth, and fate of the osteoclasts, together with a critical 



1 Contribution No. 64, January 25, 1918. A grant from the American Asso- 

 ciation for the Advancement of Science has made possible the publication of the 

 lithographic plate. 



315 



