362 S. SAGUCHI 



tion through the basal portion of the cell, as described and fig- 

 ured by Ver Eecke, Mouret ('95, '05), Zimmermann, Mathews, 

 Arnold, Mislawsky and others. Zimmermann and Mislawsky 

 have found that these parallel striations appear in both longi- 

 tudinal and transverse sections, and claim that this is, in reality, 

 nothing but a figure of the section of a lamellar system ; b) homo- 

 geneous rods or fibrillar bundles, such as seen in the figures of 

 Eberth and Muller, Solger ('94), Garnier, Prenant, and others; 

 c) comma- or crescent-shaped, or spherical, either homogeneous 

 or fibrillar bodies which are usually classified along with the so- 

 called mebenkern,' and which have been found by Eberth and 

 Muller, Ver Eecke and Mouret ('05) in the pancreatic cells. To 

 my mind, these three types are not distinct structures, but be- 

 long to one and the same system, for it is evidently seen from the 

 figures of the above authors that they are connected by all grades 

 of transition. 



The opinions of investigators are not in agreement as to the 

 genesis and significance of the fibrillar structures. 



1. Mouret ('95, '05) Mathews, Laguesse ('99), Prenant, and 

 others admit that the structures under consideration are pre- 

 formed in living cells and take part in the formation of secreting 

 matter either directly by breaking down into granules or indi- 

 rectly. Mouret and Laguesse have given the name 'substance or 

 filament prezymogene' to it. The assumption that the nucleus 

 participates in the formation of secreting matter is perhaps based 

 upon the facts that, first, a relation in position and in tingibility 

 exists betwen the nucleus and the filaments; secondly, that the 

 latter run vertically from the base, where the nucleus lies, toward 

 the top, and lose themselves among the zymogen granules; and, 

 finally, that the increase and decrease of the two are reciprocal. 

 Moreover, Mathews and Garnier believe that the filaments are 

 connected by one extremity to the nucleus and receive by this 

 means a certain substance necessary for the elaboration of the 

 secreting matter from the nucleus. They explain, in this way, 

 the similarity of the staining reactions of the two. This argument 

 and others advanced by Mathews, Garnier, and their supporters 

 are riot sufficient, at present, to warrant the unqualified accept- 



