368 S. SAGTJCHI 



do not agree with Hoven ('10, '12) that the ramification or the 

 close side-by-side apposition of chondriocontes are pictures show- 

 ing their longitudinal splitting; for it will be seen that the mul- 

 tiplication of the mitochondrial filament, as will be shown later 

 on, takes place in a quite different manner. 



In addition to long filaments, relatively short ones or rods are 

 often met with. Whether these rods are actual structures or are 

 brought about in the act of cutting sections is difficult to decide, 

 inasmuch as the production of short rods in such thin sections 

 as I have made is not unusual. 



A few words concerning the structure of the chondrioconte. 

 There are some investigators who distinguish between a cortical 

 and a marrow-substance. This claim is made when the filament 

 is shortened or thickened, or is broken down into granules, in 

 consequence of unsatisfactory fixation. In perfectly preserved 

 cells, on the contrary, the chondrioconte is always homogeneous. 



The. position of mitochondrial filaments or chondriocontes is 

 variable according to the degree of accumulation of zymogen 

 granules; generally speaking, they are crowded around the nu- 

 cleus more than elsewhere, so that they are never lacking here 

 even when they cannot be detected in the rest of the cell-body 

 (figs. 45, 47, 54) . Such relation in position between the nucleus 

 and chondriocontes was pointed out by Policard ('12), who 

 studied liver cells. He says that this relation changes but 

 slightly with the different stages of secretion. The chondrio- 

 contes below the nucleus course mainly horizontally, while at 

 the sides they ascend toward the distal end of the cell, the hori- 

 zontal filaments often passing over directly into the longitudinal 

 ones (figs. 43, 56). In case the zymogen granules are few in 

 number or are entirely lacking, the chondriocontes situated 

 over the nucleus have irregular courses (figs. 55, 56, 58, 60). 

 When the zymogen granules are densely packed together, the 

 chondriocontes do not usually enter the granular zone (figs. 44, 

 61, 79) ; so, a certain region over the nucleus, which appears clear 

 and contains only a few zymogen granules, is commonly free from 

 chondriocontes (figs. 39, 44, 61). This is characteristic of such 

 mitochondrial preparations as Benda's, Altmann's, and Meves'. 

 The significance of this region will be discussed later on. 



