378 S. SAGUCHI 



different stages of secretion, has found that they disappear from 

 the glandular cell during its activity, and that they reappear and 

 increase during the resting period. He regards the fat-droplets 

 as stored up material ; after zymogen granules have been formed 

 from the assimilated material, the remnant of the latter is used 

 up in the formation of fat-droplets. At the expense of these, 

 zymogen granules may be formed after continued fasting. Mis- 

 lawsky ('13) and Maximow ('16) have also found that the fat- 

 granules make their appearance in large numbers on pilocarpin 

 injection. According to the former author, their appearance 

 must be pathological. 



I have above mentioned that the fat-like granules are produced 

 by the transformation of mitochondria. The pilocarpin injection 

 affords an indirect confirmation of this view. As Mislawsky 

 and Maximow have observed, and I can confirm from my own 

 experience, the fat corpuscles become largely increased in number 

 by injection of that medicament. This is probably owing to the 

 fact that the production and expenditure of mitochondria are 

 thereby accelerated, which accompanies the increased production 

 of the fat-like granules. This is also in accord with the observa- 

 tion of Laguesse that the fatty granules of the pancreas cell are 

 increased in the stage of exhaustion. 



In studying the ultimate fate of the fat-like granules, we must 

 take into account that they are formed near the basal surface of 

 the cell, and are never seen to pass toward the lumen. It is 

 well within the bounds of possibility that they become used up 

 here or pass out of the cell. It would seem from their staining 

 reactions that a part of them are undergoing definite alteration 

 (fig. 64) ; though it is not certain that all of them behave in the 

 same manner. On the other hand, it must be noticed that gran- 

 ules of the same nature are often met with in the capillary blood- 

 vessels (fig. 67) or in the connective tissue separating the latter 

 from the basis of the glandular cell (figs. 66, 68). Since we have 

 now determined that the fat-like granules are formed within the 

 pancreas cell, the pictures just mentioned cannot be regarded as 

 evidence of their passage from the capillary blood-vessel toward 

 the acinus-cell, but as exhibiting their movement in the opposite 



