384 S. SAGUCHI 



they take part in the formation of zymogen granules after 

 undergoing certain changes in the cytoplasm. Galeotti ('95) 

 believes that both nucleoli and fuchsinophile granules pass out 

 of the nucleus in order to form secretion granules. 



Observations. In the previous section we have found that 

 fat-like corpuscles are formed by the disintegration of mitochon- 

 drial filaments; we see here again that zymogen granules are 

 derived from the chondriocontes. 



I have before pointed out that there is an area between the 

 nucleus and the free end of the cell, which either appears clear 

 in consequence of the absence of secretion granules or is dis- 

 tinctly marked off from the adjacent cytoplasm (figs. 39, 61, 

 75, 76, 78). Since the elaboration of zymogen granules takes 

 place in this area, it can well be termed 'secretogenous area.' 

 The process is as follows: the mitochondrial filaments or chon- 

 driocontes first converge to this area; some of them being passed 

 into it (fig. 71). In other preparations there can be seen small 

 granules, the diameter of which is as large as, or a little larger 

 than, that of the chondriocontes (fig. 73). To see how they 

 have been formed, we must take another preparation, in which 

 there can be observed chondriocontes carrying spherical swell- 

 ings (figs. 72, 77). These different pictures must be regarded 

 as one and the same process going on in such a manner that 

 the chondriocontes disintegrate into granules in this area. These 

 small granules, for which it will be better to reserve the name 

 'prozymogen granules,' because of the fact that they give rise 

 to zymogen granules, are at first few in number, but they become 

 gradually augmented in consequence of the breaking down of 

 chondriocontes entering the area in succession (fig. 73). It 

 must be observed especially, in this connection, that the chon- 

 driocontes of the pancreas cell, except those which are located 

 close to the cell basis and in the secretogenous area, can neither 

 be seen carrying spherical swellings nor breaking down into 

 granules; an observation upon which I lay considerable stress as 

 differing from those investigators who believe in the break- 

 ing down of chondriocontes into granules everywhere in the 

 cell-body. 



