394 S. SAGTJCHI 



injection mass is passed into the spaces within the cell. The 

 latter, in part at least, correspond to the granules or droplets 

 lying at the lateral cell margin and connected with the inter- 

 cellular capillary, as seen in the Cajal and Flemming prepara- 

 tion (figs. 97, 98, 101 to 104). That the button-like secre- 

 tion vacuoles communicate with the intercellular canaliculi 

 was noticed by Kupffer, as early as 1873, in an injection prepara- 

 tion of the liver; Retzius ('92), using the Golgi method, found, 

 in salivary glands, drop-like appendages on the intercellular 

 canaliculus, which must be, according to him, the same thing 

 as Kupffer's secretion vacuoles. In the pancreas, similar vacuoles 

 were also described by Muller ('98) as lying near the lumen or 

 the intercellular canaliculi. Furthermore, it must be taken 

 into consideration that the attachment of the projections or 

 droplets derived from the network to the lateral cell margin is 

 limited to the upper half or two-thirds of the height of the cell, 

 where the intercellular canaliculus will just be found. This 

 also strongly suggests that the two are in close relation to each 

 other. 



From the preceding observations and considerations, I have 

 been led to the conclusion that the substance composing the 

 intracellular network is formed in some way within the cell- 

 body and is to be eliminated from the cell. This view is 

 strikingly at variance with that of Holmgren ('02), who claims 

 that the intracellular network or his 'trophospongium' in the 

 pancreatic cell, just as in other kinds of cells, especially in the 

 nerve cell, is of exogenous origin. In spite of a more careful 

 study, I have never been able to find out the connection between 

 the cords of the network and the basket- or centroacinal cells, 

 as has been described and figured by this author. 



Now arises the question as to the genesis of the intracellular 

 network. It is exceedingly difficult to determine whether the 

 network is perfectly impregnated or not. The examination of 

 those cells which contain no zymogen granules or only a small 

 number of them showed that the network is well developed in 

 some cells, while in others it is totally lacking; there being 

 intermediate conditions between these two extremes. In the 



